Jiangsu, China
Business Type:
Manufacturer/Factory & Trading Company
Number of Employees:
2921
Year of Establishment:
1995-03-28
Management System Certification:
GMP
Average Lead Time:
Peak season lead time: one month
Off season lead time: one month
OEM/ODM Service
Sample Available
Spanish Speaker

West Medicine, Medicine, Pharmaceutical manufacturer / supplier in China, offering Amoxicillin and Clavulanate Potassium Granule, Pemetrexed Disodium for Injection, Edaravone Injection and so on.

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Supplier Homepage Products Anti-infection Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule
  • Amoxicillin and Clavulanate Potassium Granule

Amoxicillin and Clavulanate Potassium Granule

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Min. Order: 300,000 sachet
Port: Shanghai, China
Production Capacity: 100, 000, 000
Payment Terms: L/C, T/T, D/P, Western Union, Paypal
Application: Internal Medicine
Usage Mode: For oral administration
Suitable for: Elderly, Adult
State: Granule
Shape: Powder
Type: Medicine

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Basic Info

Model NO.
156.25mg
Pharmaceutical Technology
Chemical Synthesis
Drug Reg./Approval No.
H10950244
Trademark
AnQi
Transport Package
Box Carton
Specification
156.25mg
Origin
China
HS Code
3004909000
Amoxicillin and Clavulanate Potassium Granules

 
Generic name: Amoxicillin and Clavulanate Potassium Granules(4:1)
Brand name: Anqi
Composition:
Amoxicillin :(2S,5,R,6,R)-6-[(,R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
Clavulanate potassium :(Z)(2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1 azabicyclo[3.2.0]-heptane-2-carboxylate
Chemical structure:
Amoxicillin and Clavulanate Potassium Granule

 
Molecular formula: C16H19N3O5S•3H2O,C8H8KNO5
Molecular weight:419.45,237.25
Description: Anqi is granular and powder; aromatic, sweet.
Indications:This product is indicated  for the treatment of infections caused by sensitive bacteria, such as:
1  Upper Respiratory Tract Infection: sinusitis, tonsillitis, pharyngitis ,etc.
2  Lower Respiratory Tract infection: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia,
lung abscess and complicated bronchial infection.
3  Urinary Tract Infections: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, urinary
tract infections caused by Neisseria gonorrhoeae and soft chancre.
4  Skin and Soft Tissue Infections: boils, abscesses, cellulitis, wound infection, intra-abdominal sepsis etc.
5  Other Infections: otitis media, osteomyelitis, septicemia, peritonitis and postoperative infection etc.
Strength:156.25mg(4:1)
Dosage and Administration:
Taken orally.For adults and children more than 12 years old, 2 packets each time, 3 times daily; and for
children between 7 to 12 years old, 1.5 packets each time, 3 times daily; and for children between 1 to7 years
old,1 packet each time, 3 times daily; and for children between 3 months to 1 years old, 0.5 packet each time,
3 times daily; In the case of  serious infection, the dose can be doubled or be followed the doctor's advice.
Without re-examination, consecutive treatment period should be no more than 14 days.

Pharmacology and toxicology:
Mechanism of action:
Adco-Amoclav is a combination of amoxicillin and potassium clavulanate. The amoxicillin component of the
formulation exerts a bactericidal action against many strains of Gram positive and Gram-negative organisms.
The clavulanic acid component has little or no antimicrobial action. However, by inactivation of susceptible
beta-lactamase protect amoxicillin from degradation by beta-lactamase enzymes produced by penicillin
resistant strains of organisms.
Antibacterial Activity 
Clavulanic acid is an irreversible inhibitor of beta-lactamases produced by Staphylococcus aureus,
Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Proteus vulgaris , H. influenzae, N.
gonorrhoeae and B. fragilis( In-vitroactivity does not necessarily imply in-vivo efficacy). Potassium clavulanate
does not inactivate the chromosomally mediated (Cephalosporinase) beta-lactamases produced by Acineto
bacter species, Citrobacter species,Enterobacter, indole positive Proteus, Providencia species and Serratia
marcescens.

Pharmacokinetics:
The pharmacokinetics of amoxicillin and clavulanic acid are closely allied and neither are adversely affected
by the presence of food in the stomach, and are stable in the presence of gastric acid. The oral bioavailability
of amoxicillin and potassium clavulante is approximately 90% and 75% respectively.
Peak serum levels of both occur about 1-2 hour after oral administration. Clavulanic acid has about the same
plasma elimination half-life (1 hour) as that of amoxicillin (1,3 hours). Adco-Amoclav Suspension is eliminated
primarily unchanged through the renal route (glomerularfiltration and tubular secretion). Approximately 50-78%
of amoxicillin and 25-40% of clavulanic acid are excreted unchanged in urine within the first 6 hrs after
administration.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Side effects 
Amoxicillin
Sensitivity reactions are more likely to occur in individuals who have previously demonstrated hypersensitivity
to penicillins and in those with a history of allergy, asthma, hay fever or urticaria.The hypersensitivity reactions
reported are erythematous maculopapular rashes,  fever and joint pains. Anaphylactic shock may occur.

Gastrointestinal
Nausea, heartburn, vomiting and diarrhoea.
Pseudomembranous colitis has been reported.

Liver
Hepatotoxicity, hepatitis, cholestatic jaundice may occur. A moderate rise in serum glutamic oxalacetic
transaminase (SGOT) has been noted, but the significance of this finding is unknown.

Hemic and Lymphatic Systems 
Anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia and granulocytopenia have
been reported during therapy with Adco-Amoclav. These reactions are usually reversible on discontinuation
of therapy and are believed to be hypersensitivity phenomena.

Central Nervous System
Reversible hyperactivity, agitation, anxiety, insomnia, confusion, behavioural changes, and/or dizziness have
also been reported. Depression, seizures, or hallucinations.
Other A sore mouth or tongue and a black hairy tongue have been reported.
Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and
vasculitis, may occur. Erythema multiforme (including Stevens Johnson syndrome), toxic episodes of
necrolysis.
Storage:Store below 25°C, protected from moisture.
After reconstitution the product must be stored at 2-8°C in a refrigerator. In order to maintain stability,
the prepared suspension must under no circumstances be stored outside the fridge.
The prepared suspension should be consumed within 7 days of preparation.

Packs:156.25mg /sachet,  6 sachets/Box
Shelf-life:24 months 
Amoxicillin and Clavulanate Potassium Granule

 
              

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